CBD Bioavailability Increased by Food Intake.

Taking CBD consistently with food could maximize treatment outcomes. According to the evidence, high-fat meals ingested at the time of dosing can increase bile salt secretion, which solubilizes drugs and enhances absorption via transport through hydrophobic barriers [22].

As CBD is a highly lipophilic product with low aqueous solubility, food appears to increase its bioavailability. Food may therefore represent a significant source of variability of CBD. It is likely that patients who take CBD with food would benefit from reduced within-day variability, and the risk of poor bioavailability would be minimized. Taking CBD consistently with food could maximize treatment outcomes.

According to the study...

A Phase I, Randomized, Double-Blind, Placebo-Controlled, Single Ascending Dose, Multiple Dose, and Food Effect Trial of the Safety, Tolerability and Pharmacokinetics of Highly Purified Cannabidiol in Healthy Subjects Lesley Taylor,1 Barry Gidal,2 Graham Blakey,3 Bola Tayo,1 and Gilmour Morrison

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6223703/

CBD reached steady state after approximately 2 days, with moderate accumulation (1.8- to 2.6-fold) after 750 and 1500 mg CBD twice daily. After 7 days, a twofold increase in CBD dose resulted in 1.6- and 1.9-fold increases in geometric mean Cmax and area under the plasma concentration-time curve over a dosing interval (AUCτ), respectively. CBD elimination was multiphasic; the terminal elimination half-life was approximately 60 h after 750 and 1500 mg CBD twice daily; and effective half-life estimates ranged from 10 to 17 h. Cmax was 541.2 ng/mL and AUCτ was 3236 ng·h/mL after 1500 mg CBD twice daily. A high-fat meal increased CBD plasma exposure (Cmax and AUCt) by 4.85- and 4.2-fold, respectively; there was no effect of food on tmax or terminal half-life.

After single oral doses, CBD appeared rapidly in plasma; time to maximum plasma concentration (tmax) was approximately 4–5 h

After single oral doses, CBD appeared rapidly in plasma; time to maximum plasma concentration (tmax) was approximately 4–5 h